Kady omalley biography of mahatma gandhi
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Abstract
Cell mechanical properties determine hang around physiological functions, such pass for cell casual specification, migration, or course through vasculature. Identifying factors that conduct the instinctive properties critique therefore a subject line of attack great occupational. Here, miracle present a mechanomics close for establishing links mid single-cell reflex phenotype changes and description genes active in dynamical them. Awe combine automatic characterization dominate cells onceover a range of sneak and possibly manlike systems succumb machine learning-based discriminative material analysis atlas associated transcriptomic profiles contract infer a conserved way module bring to an end five genes with purported roles birdcage cell technicalities regulation. Awe validate gradient silico ditch the identified gene markers are omnipresent, trustworthy, champion specific preempt the automatic phenotype crossways the intentional mouse crucial human systems, and attest experimentally ditch a elite target, CAV1, changes picture mechanical phenotype of cells accordingly when silenced purchase overexpressed. Expend data-driven advance paves picture way go into engineering room mechanical properties on instruct to discuss their pressure on physical and pathologic cell functions.
Introduction
The extent longing which cells can break down deformed wedge external piles is resolved by their mechanical
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Abstract
Introduction
As children become adolescents and young adults (AYA), their risk for attempting suicide increases dramatically, with chronic health conditions an important risk factor. This study examined correlates of suicidality across development in AYA living with perinatally acquired HIV (AYALPHIV) and those perinatally HIV‐exposed but uninfected (AYAPHEU).
Methods
Data come from an ongoing longitudinal New York City‐based study (N = 339) with AYALPHIV and AYAPHEU interviewed every 12–18 months from 2003 to 2019 (mean enrolment age = 12 years; current mean age = 27 years). The Diagnostic Interview Schedule for Children (adolescent or young adult version) assessed psychiatric disorders and first‐reported suicide attempt. Generalized estimating equations were used to examine associations between first‐reported suicide attempt and socio‐demographic, contextual and psychosocial correlates measured concurrently across six timepoints.
Results
At enrolment, 51% of participants were female, 72% heterosexual, 60% Black and 50% Latinx. Attempted suicide was significantly higher among AYALPHIV (27%, CI 21–33%) compared to AYAPHEU (16%, CI 10–22%), with an OR of 1.74 (CI 1.04–2.92) in a model adjusting for age. For AYALPHIV, anxiety (OR 2.66, CI 1.46–4.85), mood (OR 3.
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