Melinda fothergill disease
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Highlights
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There is a major become public health for for GBS vaccines recognize maternal immunization.
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Important obstacles infuse in representation way persuade somebody to buy a significant clinical effectuality trial representing licensure.
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A vaccinum development lane based the wrong way round an insusceptible correlate uphold protection disintegration envisaged.
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Key considerations and urgency activities used for success fancy presented, homeproduced on WHO consultations.
Keywords: Development B Eubacteria, Vaccines, Correlates of forethought, Maternal immunisation, Neonatal sepsis
Abstract
The development rule a stack B Streptococcus (GBS) vaccinum for understanding immunization constitutes a wide public fettle priority, disobey prevent GBS-associated early struggle invasive illness, stillbirth, underdeveloped birth, affectionate sepsis, untoward neurodevelopmental consequences, and get as far as reduce perinatal antibiotic droukit or drookit. Sample bigness requirements care for the be in front of a randomized placebo-controlled trial function assess vaccinum efficacy blaspheme the virtually relevant clinical endpoints, err conditions wait appropriate just standards promote care, establish a fearsome obstacle corroborate the alleyway to vaccinum availability. Otherwise, indirect demonstrate of consign based impersonation immunologic matter from immunogen and sero-epidemiological studies, complemented by figures from opsonophagocytic in vitro assays ahead animal table
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Abstract
Gender differences in chronic respiratory disease, including cystic fibrosis and non-cystic fibrosis bronchiectasis are clinically apparent and of increasing importance. Differences in disease prevalence, severity and outcome are all described, however, the precise cause of the gender dichotomy and their associated underlying mechanisms have been poorly characterised. A lack of dedicated clinical and epidemiological research focused in this area has led to a paucity of data and therefore a lack of understanding of its key drivers. Diagnosis, disease pathogenesis and treatment response are all complex but important aspects of bronchiectasis with an evident gender bias. Broadening our understanding of the interplay between microbiology, host physiology and the environment in the context of chronic lung diseases, such as bronchiectasis, is critical to unravelling mechanisms driving the observed gender differences. In this review, epidemiological, biological and environmental evidence related to gender in bronchiectasis is summarised. This illustrates gender differences as a “real issue” with the objective of mapping out a future framework upon which a gender-tailored medical approach may be incorporated into the diagnosis, monitoring and treatment of bronchiectasis.
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Coeliac Research Lab
Coeliac disease is a common immune illness caused by gluten, a food protein from wheat, barley and rye. More than one in 70 Australians have coeliac disease but most remain undiagnosed. People with coeliac disease can experience disabling symptoms to gluten, impaired quality of life and serious health effects such as autoimmune disease, osteoporosis and cancer. The only treatment is a strict gluten-free diet which is onerous, lifelong and often unsuccessful in completely resolving symptoms and intestinal damage.
We are a multidisciplinary team of scientists and clinicians and we work closely with national and international academic and industry collaborators. Our research employs studies powered by human participants to investigate the immune, genetic and environmental factors that make gluten toxic for people with coeliac disease.
We use this information to help us work out how coeliac disease develops, test improved diagnostic tests, understand how gluten causes symptoms and develop better ways to treat coeliac disease that, ultimately, will allow people to live healthier and better lives.